Labcyte Echo 5xx nanopipettor

Automate the Labcyte Echo 550/555/55x dispenser

The Labcyte Echo 550 compound reformatter transfers volumes down to 2.5 nanolitres using a state-of-the-art “touchless” technology based on focused acoustic energy. Monitoring the acoustic energy reflected from the sample allows the Echo 550 to monitor the water content of dimethyl sulfoxide (DMSO) and the fluid depth in each well.

Reformatting compound libraries is a major requirement of the pharmaceutical laboratory. Nanolitre/Nanoliter transfers from mother-plate to daughter-plate eliminate the need for serial dilutions and improve accuracy and precision while saving time and money by eliminating consumables and washes.  Integration of the Echo with a robotic arm controlled by PAA’s Overlord automation software enables the productivity of the Echo to be dramatically improved.


  • Replicate and reformat compound libraries
  • Compress or expand storage plate
    • From 384- or 1536-well Echo qualified source plates
    • To 96-, 384-, 1536- or 3456-well SBS compliant destination plates
  • User-developed protocols include:
    • Variable volume transfers from any source well to any destination well (Cherry-picking)
    • IC50 applications reducing sample consumption while improving results
  • Audit compound libraries for well volume and DMSO hydration


Using a PAA laboratory robot and Overlord, the Echo 550 can be automated and plates can be added and tracked sequentially through the system. Full reports of Echo 550 generated sample data and transfer information can be moved to other databases with Overlord.

When controlled by Overlord, the robotic arm can load the Labcyte Echo 550 from traditional lop loading stacks, random access stacks, as well as incubators.

The user can feed the system with a worklist generated from a LIMS or data management system for cherry picking.

The workcell can be further integrated with a wide range of bulk dispensing pipetting stations to complete the dilution of the compounds as part of the fully automated process. Full sample tracking is a standard part of these automated systems.